Regioselectivity of Reactions of Nitrogen and Carbon Nucleophiles with Coumarin Derivatives

Reaction of various 3-substituted coumarins with nitrogen and carbon nucleophiles appears to involve, in all cases examined, exclusive, direct substitution at the exocyclic C-1′ electrophilic center.

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Bibliographic Details
Published in:Synthetic communications 2004, Vol.34 (18), p.3409-3417
Main Authors: Kaye, Perry T., Musa, Musiliyu A.
Format: Article
Language:English
Subjects:
Coumarins
Nucleophilic substitution
Regioselectivity
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Description
Summary:Reaction of various 3-substituted coumarins with nitrogen and carbon nucleophiles appears to involve, in all cases examined, exclusive, direct substitution at the exocyclic C-1′ electrophilic center.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-200030643