Three-Component One-Pot Synthesis of 1,4-Dihydropyrano[2,3-c]pyrazole Derivatives in Aqueous Media

6-Amino-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles were synthesized by three-component reaction of aromatic aldehydes, malononitrile, and 3-methyl-1-phenyl-2-pyrazolin-5-one using triethylbenzylammonium chloride (TEBA) as catalyst in aqueous media. The reaction has the advantages of good yield...

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Bibliographic Details
Published in:Synthetic communications 2004-01, Vol.34 (24), p.4557-4563
Main Authors: Shi, Daqing, Mou, Jie, Zhuang, Qiya, Niu, Lihui, Wu, Nan, Wang, Xiangshan
Format: Article
Language:English
Subjects:
1,4-dihydropyrano[2,3-c]pyrazoles
Aqueous media
One-pot synthesis
Three component
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Summary:6-Amino-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles were synthesized by three-component reaction of aromatic aldehydes, malononitrile, and 3-methyl-1-phenyl-2-pyrazolin-5-one using triethylbenzylammonium chloride (TEBA) as catalyst in aqueous media. The reaction has the advantages of good yield, less pollution, ease of separation, and of being environment friendly.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-200043224