APPLICATION OF X-RAY FLUORESCENCE TO DETERMINATION OF METALS IN COMMERCIAL TABLETS CONTAINING DIGOXIN

With the aid of the analytical energy dispersive X-ray fluorescence technique with radioisotope excitation, the concentrations of metals in commercial tablets containing 0.25 mg of digoxin were estimated. Concentrations ranging from 2.99 to 10.70 µg of Fe; 1.59 to 2.30 µg of Ni; 0.94 to 5.48 µg of C...

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Bibliographic Details
Published in:Journal of trace and microprobe techniques 2002-02, Vol.20 (1), p.141-149
Main Authors: Zucchi, O. L. A. D., Filho, V. F. Nascimento, Neto, H. Salvio
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Cardiotonic
Digoxin
Elemental analysis
General pharmacology
Medical sciences
Pharmacology. Drug treatments
X-ray fluorescence
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Summary:With the aid of the analytical energy dispersive X-ray fluorescence technique with radioisotope excitation, the concentrations of metals in commercial tablets containing 0.25 mg of digoxin were estimated. Concentrations ranging from 2.99 to 10.70 µg of Fe; 1.59 to 2.30 µg of Ni; 0.94 to 5.48 µg of Cu and 0.11 to 5.72 µg of Zn were found per tablet analyzed. The experimental detection limits for these elements varied from 13.03 to 22.57 µg l −1 , while the relative errors made in the quantification of these metals were lower than 15%.
ISSN:0733-4680
1532-2270
DOI:10.1081/TMA-120002467