Cross-Reactivity of Antivenom

Antivenom cross-reactions have been studied using immunologic techniques, immunodiffusion, immunoelectrophoresis, immunoblotting and ELISA. Cross precipitation does not necessarily mean that there is cross protection. However, a cross protection is generally observed between closely related species....

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicology. Toxin reviews 2003-01, Vol.22 (1), p.91-113
Main Authors: Pakmanee, Narumol, Khow, Orawan, Chanhome, Lawan, Aeksowan, Surasak, Chulasugandha, Pannipa, Sitprija, Visith
Format: Article
Language:English
Subjects:
Antivenom
Cross-reactivity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antivenom cross-reactions have been studied using immunologic techniques, immunodiffusion, immunoelectrophoresis, immunoblotting and ELISA. Cross precipitation does not necessarily mean that there is cross protection. However, a cross protection is generally observed between closely related species. Cross-reactivity of monovalent antivenoms and polyvalent antivenoms among various venoms are described. The results strongly suggest the presence of genus specificity in each antivenom. Cross-reactions of antivenoms are difficult to foretell and they necessitate individual verification. Knowledge of cross-reactivity of antivenoms is a very important tool to identify for phylogenic relationships of snake species and variation in venoms, and to be a guide for effective treatment of snake bite.
ISSN:0731-3837
DOI:10.1081/TXR-120019564