Synthesis and characterization of PLGA nanoparticles

Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2006-01, Vol.17 (3), p.247-289
Main Authors: Astete, Carlos E., Sabliov, Cristina M.
Format: Article
Language:English
Subjects:
CHARACTERIZATION
Diffusion
Drug Delivery Systems
EMULSION EVAPORATION
Emulsions - chemistry
Lactic Acid - chemical synthesis
Lactic Acid - chemistry
NANOPARTICLES
Nanostructures - chemistry
Nanotechnology - methods
PLGA
Polyglycolic Acid - chemical synthesis
Polyglycolic Acid - chemistry
Polymers - chemical synthesis
Polymers - chemistry
SIZE
Solvents - chemistry
SYNTHESIS
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensively describe the top-down synthesis techniques available for PLGA nanoparticle formation, as well as the techniques commonly used for nanoparticle characterization. Many examples are discussed in detail to provide the reader with an extensive knowledge base on the important parameters specific to the synthesis method described and ways in which these parameters can be manipulated to control the nanoparticle physical characteristics.
ISSN:0920-5063
1568-5624
DOI:10.1163/156856206775997322