Peripheral nerve regeneration through guidance tubes

Biological nerve grafts have been extensively utilized in the past to repair peripheral nerve injuries. More recently,the use of synthetic guidance tubes in repairing these injuries has gained in popularity.This review focuses on artificial conduits, nerve regeneration through them, and an account o...

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Bibliographic Details
Published in:Neurological research (New York) 2004-03, Vol.26 (2), p.151-160
Main Authors: Belkas, Jason S., Shoichet, Molly S., Midha, Rajiv
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - pharmacology
Biocompatible Materials - therapeutic use
BIOMATERIAL CONSIDERATIONS
CLINICAL TRIALS
Clinical Trials as Topic - methods
Humans
Implants, Experimental
Nerve Regeneration - drug effects
Nerve Regeneration - physiology
PERIPHERAL NERVE INJURY
PERIPHERAL NERVE REPAIR
Peripheral Nerves - drug effects
Peripheral Nerves - physiology
Peripheral Nerves - transplantation
SYNTHETIC NERVE CONDUITS
TISSUE ENGINEERING
Transplants - adverse effects
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Summary:Biological nerve grafts have been extensively utilized in the past to repair peripheral nerve injuries. More recently,the use of synthetic guidance tubes in repairing these injuries has gained in popularity.This review focuses on artificial conduits, nerve regeneration through them, and an account of various synthetic materials that comprise these tubes in experimental animal and clinical trials. It also lists and describes several biomaterial considerations one should regard when designing, developing, and manufacturing potential guidance channel candidates. In the future, it it likely that the most successful synthetic nerve conduit will be one that has been fabricated with some of these strategies in mind.
ISSN:0161-6412
1743-1328
DOI:10.1179/016164104225013798