Muscle-nerve-muscle neurotization for the reinnervation of denervated somatic muscle

Muscle-Nerve-Muscle (MNM) is the reinnervation of a denervated (recipient) muscle via a nerve graft inserted into the belly of an innervated (donor) muscle. MNM is studied for the reinnervation of intrinsic denervated somatic skeletal muscle by evaluating both restored muscle contractile ability and...

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Bibliographic Details
Published in:Neurological research (New York) 2004-06, Vol.26 (4), p.388-394
Main Authors: Urbanchek, Melanie G., Ganz, Diana E., Aydin, Mustafa A., van der Meulen, Jack H., Kuzon, William M.
Format: Article
Language:English
Subjects:
Anatomy, Cross-Sectional - methods
Animals
Bungarotoxins - metabolism
Electromyography - methods
Evoked Potentials, Motor - physiology
Functional Laterality
Immunohistochemistry - methods
Models, Animal
Muscle Contraction - physiology
MUSCLE DENERVATION
Muscle Fibers, Skeletal - physiology
Muscle Fibers, Skeletal - transplantation
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
NERVE REGENERATION
Nerve Regeneration - physiology
Nerve Transfer
NEURAL CELL ADHESION MOLECULES
Neural Cell Adhesion Molecules - metabolism
Random Allocation
Rats
Rats, Inbred F344
Tolonium Chloride
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Summary:Muscle-Nerve-Muscle (MNM) is the reinnervation of a denervated (recipient) muscle via a nerve graft inserted into the belly of an innervated (donor) muscle. MNM is studied for the reinnervation of intrinsic denervated somatic skeletal muscle by evaluating both restored muscle contractile ability and innervation state. In a rat model, muscle function is tested following MNM neurotization from an innervated (donor), extensor digitorum longus muscle to a denervated (recipient), peroneus digit quinti (PDQ) muscle. PDQ muscle cross-sections labeled for neural cell adhesion molecule protein (NCAM), a marker for fiber denervation. MNM neurotization results in the recovery of PDQ muscle force generating capacity (58% of Normal-control) and a significantly lower percentage of residual muscle fiber denervation (38% denervated) compared with the Denervated-control (79% denervated) group. MNM neurotization reinnervates 62% of the previously denervated muscle fibers in the PDQ muscle. No decrement in force capacity is observed in the donor EDL muscle. Nerve grafting for MNM neurotization may restore modest contractile function to denervated muscle and reinnervate relatively more denervated muscle fibers than the Denervated-control.
ISSN:0161-6412
1743-1328
DOI:10.1179/016164104225013824