Expression of DeltaNp73 in hippocampus of APP/PS1 transgenic mice following GFP-BMSCs transplantation

Objective: To study the effect of hippocampal bone marrow stromal cells (GFP-BMSCs) transplantation on spatial memory and DeltaNp73 expression in APP/PS1 transgenic mice. Methods: Twelve APP/PS1 transgenic mice randomly received either 10 μl GFP-BMSCs suspension in medium (GFP-BMSCs transplantation...

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Bibliographic Details
Published in:Neurological research (New York) 2011-12, Vol.33 (10), p.1109-1114
Main Authors: Wen, Shi-Rong, Qi, Hui-Ping, Ren, Ya-Jing, Liu, Guo-Jun, Gong, Feng-Chao, Zhong, Hua, Bi, Sheng
Format: Article
Language:English
Subjects:
Alzheimer's disease
APP/PS1 transgenic mice
DeltaNp73
GFP-BMSCs
Transplantation
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Summary:Objective: To study the effect of hippocampal bone marrow stromal cells (GFP-BMSCs) transplantation on spatial memory and DeltaNp73 expression in APP/PS1 transgenic mice. Methods: Twelve APP/PS1 transgenic mice randomly received either 10 μl GFP-BMSCs suspension in medium (GFP-BMSCs transplantation group) or 10 μl complete medium (sham-operated group). Learning and memory function of mice in both groups were observed and tested in Morris water maze experiment at 2 weeks after surgery. Senile plaques and DeltaNp73 protein in hippocampuses were determined by immunohistochemistry and western blot at 3 weeks after surgery, respectively. Results: APP/PS1 mice treated with BMSCs performed significantly better on the water maze test than those in sham-operated group (P
ISSN:0161-6412
1743-1328
DOI:10.1179/1743132811Y.0000000051