Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka

Plasma levels of pro- and anti-inflammatory cytokines of Plasmodium falciparum-infected patients with severe malaria (SM; n = 62) and uncomplicated malaria (UM; n = 69) from Sri Lanka were assessed. SM patients had significantly higher levels of TNF-alpha (P

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Bibliographic Details
Published in:Pathogens and global health 2013-01, Vol.107 (1), p.21-29
Main Authors: Perera, M. K., Herath, N. P., Pathirana, S. L., Phone-Kyaw, M., Alles, H. K., Mendis, K. N., Premawansa, S., Handunnetti, S. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Child
Child, Preschool
Female
General aspects
Genetic Association Studies
Human protozoal diseases
Humans
Infant
Infectious diseases
Interleukin-10
Interleukin-10 - blood
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - genetics
Malaria, Falciparum - parasitology
Malaria, Falciparum - pathology
Male
Medical sciences
Middle Aged
Original
P. falciparum
Parasitic diseases
Plasmodium
Plasmodium falciparum
Plasmodium falciparum - physiology
Protozoal diseases
Severe malaria
Sri Lanka
Tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - genetics
Young Adult
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Description
Summary:Plasma levels of pro- and anti-inflammatory cytokines of Plasmodium falciparum-infected patients with severe malaria (SM; n = 62) and uncomplicated malaria (UM; n = 69) from Sri Lanka were assessed. SM patients had significantly higher levels of TNF-alpha (P
ISSN:2047-7724
2047-7732
DOI:10.1179/2047773212Y.0000000069