Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato [Lycopersicon esculentum] paste

Lycopene is known to decrease cardiovascular risks. The objective of this study was to investigate the molecular mechanisms of tomato paste containing approximately 0.1% lycopene in regulating lipid metabolism and oxidation. Hamsters fed 3% or 9% tomato paste containing 0.2% cholesterol were subject...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-03, Vol.72 (3), p.677-685
Main Authors: Hsu, Y.M.(China Medical Univ., Taichung (Taiwan)), Lai, C.H, Chang, C.Y, Fan, C.T, Chen, C.T, Wu, C.H
Format: Article
Language:English
Subjects:
Adenylate Kinase - analysis
Adenylate Kinase - physiology
Animals
ANTIOXIDANTES
ANTIOXIDANTS
Antioxidants - pharmacology
ANTIOXYDANT
atherogenesis
Biological and medical sciences
Biomarkers - blood
Carbonic Anhydrase III - analysis
Carbonic Anhydrase III - physiology
Carotenoids - administration & dosage
Carotenoids - pharmacology
CHOLESTEROL
COLESTEROL
Cricetinae
Food Handling
Fundamental and applied biological sciences. Psychology
HAMSTER
HAMSTERS
Isoenzymes - analysis
Isoenzymes - physiology
LICOPENO
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
LIPIDE
LIPIDOS
LIPIDS
Lipids - blood
LYCOPENE
Lycopersicon esculentum
Mesocricetus
OXIDACION
OXIDATION
OXYDATION
PUBLIC HEALTH
SALUD PUBLICA
SANTE PUBLIQUE
SUPEROXIDE DISMUTASE
SUPEROXIDO DISMUTASA
SUPEROXYDE DISMUTASE
TOMATE
tomato paste
TOMATOES
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Summary:Lycopene is known to decrease cardiovascular risks. The objective of this study was to investigate the molecular mechanisms of tomato paste containing approximately 0.1% lycopene in regulating lipid metabolism and oxidation. Hamsters fed 3% or 9% tomato paste containing 0.2% cholesterol were subjected to total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG) measurements. Our results showed reduced rates of serum TC and LDL levels due to 9% tomato paste were 14.3% and 11.3% respectively. Concentrations of 3% and 9% of tomato paste after 8 weeks of feeding significantly increased serum HDL levels, by 19.4% and 28.8% respectively. After ingestion of tomato paste for 8 weeks, the plasma malondialdehyde (MDA) levels significantly decreased, by 80.18% and 89.33% respectively, as compared to the cholesterol group. MDA and diene conjugation assays indicated the potent antioxidant activity of the tomato paste. The increased activities of superoxide dismutases (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), further supported the antioxidant effects of the tomato paste. Two dimension-gel electrophoresis (2-DE) analysis revealed that carbonic anhydrase III (CAIII) and adenylate kinase 2 (AK2) may be two important regulators involved in the anti-lipid and antioxidant effects of tomato paste, opening new insight into the nutritional value of tomato in public health promotion.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.70402