Digestion and absorption of Siraitia grosvenori triterpenoids in the rat

When administered to rats, mogroside V (a pentaglucose-conjugated mogroside), the main sweetening component of Siraitia grosvenori, was mostly degraded by digestive enzymes and intestinal microflora, and was excreted in the feces as mogrol (aglycone) and its mono- and diglucosides. However, trace am...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (3), p.673-676
Main Authors: Murata, Y., Saraya Co. Ltd., Kashiwara, Osaka (Japan). Biochemical Lab, Ogawa, T, Suzuki, Y.A, Yoshiakwa, S, Inui, H, Sugiura, M, Nakano, Y
Format: Article
Language:English
Subjects:
ABSORCION
ABSORPTION
aglycone
Animals
APPAREIL DIGESTIF
Biological and medical sciences
Blood Glucose - drug effects
conjugate
DIGESTION
DIGESTIVE SYSTEM
Fruit - chemistry
Fundamental and applied biological sciences. Psychology
GLICOSIDOS
Glucuronides - metabolism
GLYCOSIDE
GLYCOSIDES
http://www.fao.org/aos/agrovoc#c_2271
http://www.fao.org/aos/agrovoc#c_2275
http://www.fao.org/aos/agrovoc#c_27
http://www.fao.org/aos/agrovoc#c_27616
http://www.fao.org/aos/agrovoc#c_3309
http://www.fao.org/aos/agrovoc#c_4902
http://www.fao.org/aos/agrovoc#c_6464
Intestinal Absorption
mogroside V
MOMORDICA
Momordica - chemistry
RAT
RATA
RATS
Rats, Wistar
Siraitia grosvenori Swingle
SISTEMA DIGESTIVO
Sweetening Agents - administration & dosage
Sweetening Agents - metabolism
TERPENOIDE
TERPENOIDOS
TERPENOIDS
Triterpenes - administration & dosage
Triterpenes - metabolism
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Summary:When administered to rats, mogroside V (a pentaglucose-conjugated mogroside), the main sweetening component of Siraitia grosvenori, was mostly degraded by digestive enzymes and intestinal microflora, and was excreted in the feces as mogrol (aglycone) and its mono- and diglucosides. However, trace amounts of mogrol and its monoglucoside were found in the portal blood as sulfates and/or glucuronide conjugates.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.90832