Influence of Antioxidants on Blood-Brain Barrier Permeability During Adrenaline-Induced Hypertension

• Published in: International journal of neuroscience 2000-01, Vol.105 (1-4), p.27-35
• Main Authors: Özta, B., Erkin, E., Dural, E., Isbir, T.
• Format: Article
• Language: English
• Subjects: Adrenaline; Animals; Antioxidants - pharmacology; Biological and medical sciences; Blood brain barrier (BBB); Blood-Brain Barrier - drug effects; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Coloring Agents; Epinephrine; Evans Blue; Female; Free radicals; Fundamental and applied biological sciences. Psychology; Hypertension - chemically induced; Hypertension - physiopathology; Rats; Rats, Wistar; Selenium; Selenium - pharmacology; Vertebrates: nervous system and sense organs; Vitamin E; Vitamin E - pharmacology
• ISSN: 0020-7454; 1563-5279; 1543-5245
• DOI: 10.3109/00207450009003263

We have examined the effect of antioxidants (vitamin E, and selenium) on the blood brain barrier permeability during adreneline-induced acute hypertension in the female rats. The rats supplemented with nontoxic doses of sodium selenite in drinking water for three months or vitamin E was given intraperitoneally before adrenaline-induced acute hypertension. Evans-blue was used as a blood-brain barrier tracer. Mean values for Evans-blue dye were found to be 0.28±0.04 μg/g tissue in control animals and 1.0±0.2 μg/g tissue after adrenaline-induced acute hypertension (p . 5). The mean value for Evans-blue dye was found to be 1.0±0.2 μg/g tissue in acute hypertension group, 0.9±0.2 μg/g tissue in selenium pretreated animals and 1.0±0.2 μg/g tissue vitamin E injected animals after acute hypertension. The results show that antioxidants did not influence the blood-brain barrier breakdown during adrenaline-induced acute hypertension.