Circulating fibronectin isoforms predict the degree of fibrosis in chronic hepatitis C

Abstract Objective. Hepatic stellate cells only produce fibronectin isoforms in disease states. The isoform-defining domains can be detected in the blood circulation. This study examines whether circulating levels of fibronectin isoforms show a relationship with liver fibrosis on histology in patien...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2010-03, Vol.45 (3), p.349-356
Main Authors: Hackl, Norman J., Bersch, Claus, Feick, Peter, Antoni, Christoph, Franke, Andreas, Singer, Manfred V., Nakchbandi, Inaam A.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Biopsy, Needle
Case-Control Studies
Chronic hepatitis C
Cross-Sectional Studies
Female
fibronectin
Fibronectins - blood
fibrosis
Hepatic Stellate Cells - metabolism
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - pathology
Humans
isoform
liver biopsy
Liver Cirrhosis - blood
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Male
Middle Aged
Predictive Value of Tests
Protein Isoforms - blood
stellate cell
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Summary:Abstract Objective. Hepatic stellate cells only produce fibronectin isoforms in disease states. The isoform-defining domains can be detected in the blood circulation. This study examines whether circulating levels of fibronectin isoforms show a relationship with liver fibrosis on histology in patients with chronic hepatitis C. Material and methods. In a prospective study, 50 patients with chronic hepatitis C who underwent a liver biopsy were compared to 50 matched controls and 35 patients with other liver conditions. Results. Circulating levels of the fibronectin isoforms were significantly higher in patients with chronic hepatitis C compared to healthy controls [oncofetal fibronectin (oFN) 2.45 ± 0.17 versus 1.76 ± 0.16 mg/l, P
ISSN:0036-5521
1502-7708
DOI:10.3109/00365520903490606