Percentages of CD4+ T regulatory cells and HLA-DR expressing monocytes in severe intra-abdominal infections

Abstract To study the immune status of patients with severe abdominal infections, we assayed percentages of CD4+ T regulatory cells (CD4+CD25+FOXP3+ Treg) and human leukocyte antigen DR (HLA-DR) expressing CD14+ cells in peripheral blood. A total of 46 subjects with varying acute physiology and chro...

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Published in:Scandinavian journal of infectious diseases 2010-07, Vol.42 (6-7), p.475-478
Main Authors: Qiang, Fu, Naiqiang, Cui, Wenli, Yu, Chao, Du
Format: Article
Language:English
Subjects:
Abdominal Cavity - physiopathology
Aged
Analysis of Variance
APACHE
Biological and medical sciences
Female
Forkhead Transcription Factors - metabolism
HLA-DR Antigens - metabolism
Humans
Infection - metabolism
Infectious diseases
Interleukin-2 Receptor alpha Subunit - metabolism
Male
Medical sciences
Middle Aged
Monocytes - metabolism
Sepsis - metabolism
T-Lymphocytes, Regulatory - metabolism
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cited_by cdi_FETCH-LOGICAL-c435t-51187ad621eff51e26eff6e98c287e0805a4253c52869a182076e48bb5fa28923
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container_end_page 478
container_issue 6-7
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container_title Scandinavian journal of infectious diseases
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creator Qiang, Fu
Naiqiang, Cui
Wenli, Yu
Chao, Du
description Abstract To study the immune status of patients with severe abdominal infections, we assayed percentages of CD4+ T regulatory cells (CD4+CD25+FOXP3+ Treg) and human leukocyte antigen DR (HLA-DR) expressing CD14+ cells in peripheral blood. A total of 46 subjects with varying acute physiology and chronic health evaluation II (APACHE II) scores were included in the study. There was a significant (p < 0.01) increase in the percentage of CD4+CD25+FOXP3+ Treg and a significant (p < 0.01) decrease in HLA-DR expressing CD14+ cells with increasing APACHE II score. Such modifications may contribute to the aggravation of severe intra-abdominal infections.
doi_str_mv 10.3109/00365541003660021
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subjects Abdominal Cavity - physiopathology
Aged
Analysis of Variance
APACHE
Biological and medical sciences
Female
Forkhead Transcription Factors - metabolism
HLA-DR Antigens - metabolism
Humans
Infection - metabolism
Infectious diseases
Interleukin-2 Receptor alpha Subunit - metabolism
Male
Medical sciences
Middle Aged
Monocytes - metabolism
Sepsis - metabolism
T-Lymphocytes, Regulatory - metabolism
title Percentages of CD4+ T regulatory cells and HLA-DR expressing monocytes in severe intra-abdominal infections
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