Multidisciplinary Management of Osteosarcoma: Experience in Hong Kong

All pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemothera...

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Bibliographic Details
Published in:Pediatric hematology and oncology 1998, Vol.15 (3), p.229-236
Main Authors: Kwong, D. L. W., Ha, S. Y., Chau, K. Y., Choi, P. H. K., Chan, G. C. F., Kwong, P. W. K., Lau, Y. L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Biological and medical sciences
Bone Neoplasms - drug therapy
Bone Neoplasms - epidemiology
Bone Neoplasms - pathology
Bone Neoplasms - surgery
Child
Child, Preschool
Diseases of the osteoarticular system
Female
Hong Kong - epidemiology
Humans
Male
Medical sciences
multidisciplinary care
Neoplasm Metastasis
osteosarcoma
Osteosarcoma - drug therapy
Osteosarcoma - epidemiology
Osteosarcoma - pathology
Osteosarcoma - surgery
pediatric
Recurrence
Survival Analysis
Tumors of striated muscle and skeleton
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Summary:All pediatric osteosarcomas treated in our hospital between 1985 and 1995 were reviewed. There were 26 patients, 15 males and 11 females, aged 20 or less at diagnosis. All had limb primaries. Nineteen patients had localized disease and seven presented with metastases. Intensive multiagent chemotherapy was given both pre-and postoperatively. Most patients were treated with the Rosen T10 regimen or its modifications. Only one patient had limb salvage surgery; all others had amputation. With a median follow-up of 74 months, the 5-year disease-free survival among patients with localized disease was 65.2%. Being female and having a high 6-hour postinfusion methotrexate level with a median level greater than 700 umol/L were good prognostic factors. Three of the seven patients with metastatic disease were alive at 21, 26, and 140 months after diagnosis. All of them had lung secondaries. Survival rates achieved in our center were comparable to those reported in literature. However, our amputation rate was high and further development in expertise for limb salvage treatment is a goal.
ISSN:0888-0018
1521-0669
DOI:10.3109/08880019809028789