Topical silicone gel sheet versus intralesional injections of triamcinolone acetonide in the treatment of keloids - a patient-controlled comparative clinical trial

Objective: This prospective, patient-controlled study aimed to assess the effectiveness of topical silicone gel sheet and intralesional injections of triamcinolone acetonide (40 mg/ml) in the treatment of keloids. Methods: Twenty patients with multiple keloids were recruited for this study which las...

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Published in:The Journal of dermatological treatment 1999, Vol.10 (4), p.251-254
Main Authors: Tan, E, Chua, Sh, Lim, Jte
Format: Article
Language:English
Subjects:
Biological and medical sciences
Keloids
Medical sciences
Pharmacology. Drug treatments
Silicone gel sheet
Skin, nail, hair, dermoskeleton
Triamcinolone acetonide
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cited_by cdi_FETCH-LOGICAL-c292t-644b36bf8b66ab9d86f93c6697fec982f8748a3e9f773d0e0e13ad031524cc4c3
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container_title The Journal of dermatological treatment
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creator Tan, E
Chua, Sh
Lim, Jte
description Objective: This prospective, patient-controlled study aimed to assess the effectiveness of topical silicone gel sheet and intralesional injections of triamcinolone acetonide (40 mg/ml) in the treatment of keloids. Methods: Twenty patients with multiple keloids were recruited for this study which lasted 12 weeks. In each patient, three keloids of similar size were selected. One was assigned to no' treatment (control) and one to each active treatment. For treatment, patients were instructed to place the sheet over the assigned keloid for 12 h daily for 12 weeks, while intralesional injections of triamcinolone acetonide (40 mg/ml) were administered to the other assigned keloid. Results: None of the untreated control lesions showed any spontaneous reduction in size. Of the lesions treated with silicone gel sheet dressing, only 2 of 17 (12%) showed a significant reduction in size (i.e. at least 50% reduction in size) at week 12. This was not statistically significant when compared with the untreated control lesions (P> 0.05, Fisher's exact test). Of the lesions treated with intralesional injections of triamcinolone acetonide (40 mg/ml), 16 of 17 (94%) showed a significant reduction in size at week 12. This was statistically significant when compared with the untreated control lesions (P
doi_str_mv 10.3109/09546639909056040
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Methods: Twenty patients with multiple keloids were recruited for this study which lasted 12 weeks. In each patient, three keloids of similar size were selected. One was assigned to no' treatment (control) and one to each active treatment. For treatment, patients were instructed to place the sheet over the assigned keloid for 12 h daily for 12 weeks, while intralesional injections of triamcinolone acetonide (40 mg/ml) were administered to the other assigned keloid. Results: None of the untreated control lesions showed any spontaneous reduction in size. Of the lesions treated with silicone gel sheet dressing, only 2 of 17 (12%) showed a significant reduction in size (i.e. at least 50% reduction in size) at week 12. This was not statistically significant when compared with the untreated control lesions (P&gt; 0.05, Fisher's exact test). Of the lesions treated with intralesional injections of triamcinolone acetonide (40 mg/ml), 16 of 17 (94%) showed a significant reduction in size at week 12. This was statistically significant when compared with the untreated control lesions (P&lt;0.05). Of the two modalities of treatment, intralesional injections of triamcinolone acetonide (40 mg/ml) were therefore found to be significantly more effective than silicone gel sheet dressing. Conclusion: Our results do not support the use of occlusive silicone gel sheet as an effective treatment of chronic keloid scars. The effectiveness of intralesional injections of triamcinolone acetonide (40 mg/ml) was well demonstrated by this study and should remain one of the primary methods for the treatment of keloids.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.3109/09546639909056040</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Keloids ; Medical sciences ; Pharmacology. 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Methods: Twenty patients with multiple keloids were recruited for this study which lasted 12 weeks. In each patient, three keloids of similar size were selected. One was assigned to no' treatment (control) and one to each active treatment. For treatment, patients were instructed to place the sheet over the assigned keloid for 12 h daily for 12 weeks, while intralesional injections of triamcinolone acetonide (40 mg/ml) were administered to the other assigned keloid. Results: None of the untreated control lesions showed any spontaneous reduction in size. Of the lesions treated with silicone gel sheet dressing, only 2 of 17 (12%) showed a significant reduction in size (i.e. at least 50% reduction in size) at week 12. This was not statistically significant when compared with the untreated control lesions (P&gt; 0.05, Fisher's exact test). Of the lesions treated with intralesional injections of triamcinolone acetonide (40 mg/ml), 16 of 17 (94%) showed a significant reduction in size at week 12. This was statistically significant when compared with the untreated control lesions (P&lt;0.05). Of the two modalities of treatment, intralesional injections of triamcinolone acetonide (40 mg/ml) were therefore found to be significantly more effective than silicone gel sheet dressing. Conclusion: Our results do not support the use of occlusive silicone gel sheet as an effective treatment of chronic keloid scars. The effectiveness of intralesional injections of triamcinolone acetonide (40 mg/ml) was well demonstrated by this study and should remain one of the primary methods for the treatment of keloids.</description><subject>Biological and medical sciences</subject><subject>Keloids</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Silicone gel sheet</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Triamcinolone acetonide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, E</creatorcontrib><creatorcontrib>Chua, Sh</creatorcontrib><creatorcontrib>Lim, Jte</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>The Journal of dermatological treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, E</au><au>Chua, Sh</au><au>Lim, Jte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical silicone gel sheet versus intralesional injections of triamcinolone acetonide in the treatment of keloids - a patient-controlled comparative clinical trial</atitle><jtitle>The Journal of dermatological treatment</jtitle><date>1999</date><risdate>1999</risdate><volume>10</volume><issue>4</issue><spage>251</spage><epage>254</epage><pages>251-254</pages><issn>0954-6634</issn><eissn>1471-1753</eissn><abstract>Objective: This prospective, patient-controlled study aimed to assess the effectiveness of topical silicone gel sheet and intralesional injections of triamcinolone acetonide (40 mg/ml) in the treatment of keloids. Methods: Twenty patients with multiple keloids were recruited for this study which lasted 12 weeks. In each patient, three keloids of similar size were selected. One was assigned to no' treatment (control) and one to each active treatment. For treatment, patients were instructed to place the sheet over the assigned keloid for 12 h daily for 12 weeks, while intralesional injections of triamcinolone acetonide (40 mg/ml) were administered to the other assigned keloid. Results: None of the untreated control lesions showed any spontaneous reduction in size. Of the lesions treated with silicone gel sheet dressing, only 2 of 17 (12%) showed a significant reduction in size (i.e. at least 50% reduction in size) at week 12. This was not statistically significant when compared with the untreated control lesions (P&gt; 0.05, Fisher's exact test). 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Biological and medical sciences
Keloids
Medical sciences
Pharmacology. Drug treatments
Silicone gel sheet
Skin, nail, hair, dermoskeleton
Triamcinolone acetonide
title Topical silicone gel sheet versus intralesional injections of triamcinolone acetonide in the treatment of keloids - a patient-controlled comparative clinical trial
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