Hemophagocytic Syndrome Associated with Inappropiate Secretion of Antidiuretic Hormone in Lymphoma and Acute Myeloblastic Leukemia: Report of Two Cases

Hemophagocytic syndrome (HPS) is a rare clinicopathological disorder characterized by systemic proliferation of phagocytizing histiocytes associated with fever, cytopenias, lymphadenopathy, hepatosplenomegaly, and disseminated intravascular coagulopathy. We present the association of hemophagocytic...

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Bibliographic Details
Published in:Leukemia & Lymphoma 2001, Vol.42 (6), p.1401-1404
Main Authors: Demirkan, Fatih, Vural, Filiz, Özsan, G. Hayri, Özcan, M. Ali, Özkal, SermiN, Ündar, Bülent
Format: Report
Language:English
Subjects:
acute myeloblastic leukemia (AML)
anaplastic large cell lymphoma (ALCL)
hemophagocytic syndrome (HPS)
inappropriate secretion of antidiuretic hormone (SIADH)
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Summary:Hemophagocytic syndrome (HPS) is a rare clinicopathological disorder characterized by systemic proliferation of phagocytizing histiocytes associated with fever, cytopenias, lymphadenopathy, hepatosplenomegaly, and disseminated intravascular coagulopathy. We present the association of hemophagocytic syndrome associated with inappropriate secretion of antidiuretic hormone (SIADH) in two cases of hematological malignancies; anaplastic large cell lymphoma (ALCL) and acute myeloblastic leukemia (AML M4) In the patient with lymphoma, the diagnosis of lymphoma, HPS and SIADH were concurrent. In the patient with AML, HPS and SIADH were observed while the patient was in hematological remission. Thus it seems that patients with HPS may also carry a risk for the development of SIADH; the relationship with HPS and SIADH should be further investigated.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428190109097769