Transthyretin isoleucine-122 mutation in African and American blacks

The gene frequency of the transthyretin (TTR) mutation (Vall22Ile) was studied in African and African-American populations. The African populations analyzed included the Zulu and Xhosa of South Africa, and Yorubas from the city of Ibadan, Nigeria. The African-American population included patients at...

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Bibliographic Details
Published in:Amyloid 2000, Vol.7 (2), p.121-125
Main Authors: Afolabi, Isaki, Asl, Kamran Hamidi, Nakamura, Masaaki, Jacobs, Peter, Hendrie, Hugh, Benson, Merrill D.
Format: Article
Language:English
Subjects:
Adult
Africa
Aged
amyloidosis
Black or African American
Black People
cardiomyopathy
Female
hereditary
Humans
Isoleucine - genetics
isoleucine-122
Male
Middle Aged
Mutation
Prealbumin - genetics
transthyretin
United States
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Summary:The gene frequency of the transthyretin (TTR) mutation (Vall22Ile) was studied in African and African-American populations. The African populations analyzed included the Zulu and Xhosa of South Africa, and Yorubas from the city of Ibadan, Nigeria. The African-American population included patients at the Veterans Affairs (VA) Medical Center, Indianapolis, and newborns from a local hospital in Indianapolis. The Vall22Ile TTR mutation was identified in I of 55 Zulu, 0 of 34 Xhosa, 0 of 9 Nigerian subjects, 5 of 51 Veteran patients, and 3 of 103 newborns. Assuming the 2.91% prevalence in newborns to be the norm, there is a significant increased prevalence in the VA patient population.
ISSN:1350-6129
1744-2818
DOI:10.3109/13506120009146249