Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract

An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λ VI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λ VI Positive staining of subepithelial plasma...

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Bibliographic Details
Published in:Amyloid 1998, Vol.5 (1), p.49-54
Main Authors: Asl, Kamran Hamidi, Liepnieks, Juris J., Bihrle, Richard, Benson, Merrill D.
Format: Report
Language:English
Subjects:
lambda VI (λ
light chain
localized amyloidosis
urethra
urinary tract
Online Access:Get full text
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Summary:An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λ VI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λ VI Positive staining of subepithelial plasma cells with λ VI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.
ISSN:1350-6129
1744-2818
DOI:10.3109/13506129809007290