Ultrastructural abnormalities of astrocytes in the hippocampus in schizophrenia and duration of illness: A postortem morphometric study

There is a lot of evidence of astrocytic dysfunction in schizophrenia. We performed an electron microscopic morphometric study of astrocytes in the CA3 hippocampal region in 19 cases of schizophrenia and 16 normal controls. No significant group differences were found in cell size, volume fraction (V...

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Bibliographic Details
Published in:The world journal of biological psychiatry 2010-03, Vol.11 (2_2), p.282-292
Main Authors: Kolomeets, Natalya S., Uranova, Natalya
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
astrocytes
Astrocytes - ultrastructure
Case-Control Studies
Cell Nucleus - ultrastructure
Cytoplasm - ultrastructure
Disease Progression
Female
hippocampus
Hippocampus - ultrastructure
Humans
Lipofuscin - metabolism
Male
Microscopy, Electron
Middle Aged
Mitochondria - ultrastructure
morphometry
Schizophrenia
Schizophrenia - pathology
Sex Factors
ultrastructure
Young Adult
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Summary:There is a lot of evidence of astrocytic dysfunction in schizophrenia. We performed an electron microscopic morphometric study of astrocytes in the CA3 hippocampal region in 19 cases of schizophrenia and 16 normal controls. No significant group differences were found in cell size, volume fraction (Vv) and area density (Na) of mitochondria and lipofuscin granules. Young control subjects (50 years old), and young and old schizophrenic cases. No significant differences between young and old schizophrenic subgroups were found. Vv and Na of mitochondria correlated negatively (r=−0.66, r=−0.72, P21 years. than in the control group and in the subgroup of cases with duration of illness of
ISSN:1562-2975
1814-1412
DOI:10.3109/15622970902806124