Review of meningococcal vaccines with updates on immunization in adults

Meningococcal disease is a serious and global life-threatening disease. Six serogroups (A, B, C, W-135, X, and Y) account for the majority of meningococcal disease worldwide. Meningococcal polysaccharide vaccines were introduced several decades ago and have led to the decline in the burden of diseas...

Full description

Saved in:
Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2014-04, Vol.10 (4), p.995-1007
Main Authors: Zahlanie, Yorgo C, Hammadi, Moza M, Ghanem, Soha T, Dbaibo, Ghassan S
Format: Article
Language:English
Subjects:
Adolescent
Adult
adults
Humans
Immunization - statistics & numerical data
meningococcal conjugate vaccine
meningococcal disease
Meningococcal Infections - epidemiology
Meningococcal Infections - immunology
Meningococcal Infections - prevention & control
meningococcal polysaccharide vaccine
Meningococcal Vaccines - administration & dosage
Meningococcal Vaccines - adverse effects
Meningococcal Vaccines - immunology
Middle Aged
Neisseria meningitidis
recommendations
Review
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - adverse effects
Vaccines, Conjugate - immunology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Meningococcal disease is a serious and global life-threatening disease. Six serogroups (A, B, C, W-135, X, and Y) account for the majority of meningococcal disease worldwide. Meningococcal polysaccharide vaccines were introduced several decades ago and have led to the decline in the burden of disease. However, polysaccharide vaccines have several limitations, including poor immunogenicity in infants and toddlers, short-lived protection, lack of immunologic memory, negligible impact on nasopharyngeal carriage, and presence of hyporesponsiveness after repeated doses. The chemical conjugation of plain polysaccharide vaccines has the potential to overcome these drawbacks. Meningococcal conjugate vaccines include the quadrivalent vaccines (MenACWY-DT, MenACWY-CRM, and MenACWY-TT) as well as the monovalent A and C vaccines. These conjugate vaccines were shown to elicit strong immune response in adults. This review addresses the various aspects of meningococcal disease, the limitations posed by polysaccharide vaccines, the different conjugate vaccines with their immunogenicity and reactogenicity in adults, and the current recommendations in adults.
ISSN:2164-5515
2164-554X
DOI:10.4161/hv.27739