Intravaginal live attenuated Salmonella increases local antitumor vaccine-specific CD8+ T cells

We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8 + T cells in the genital mucosa of mice, without affec...

Full description

Saved in:
Bibliographic Details
Published in:OncoImmunology 2013, Vol.2 (1)
Main Authors: Decrausaz, Loane, Pythoud, Christelle, Domingos-Pereira, Sonia, Derré, Laurent, Jichlinski, Patrice, Nardelli-Haefliger, Denise
Format: Report
Language:English
Subjects:
bacterial immunostimulant
CD8
genital mucosa
human papillomavirus
T cells
vaccination
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8 + T cells in the genital mucosa of mice, without affecting E7-specific systemic responses. Here, we show that the instillation of live attenuated Salmonella enterica serovar Typhimurium similarly, though more efficiently (~15- fold), increases both E7-specific and total CD8 + T cells in the genital mucosa. Cancer immunotherapeutic strategies combining vaccination with local immunostimulation with live bacteria deserve further investigations.
ISSN:2162-402X
DOI:10.4161/onci.22944