Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the condition...

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Bibliographic Details
Published in:Oncoimmunology 2013-07, Vol.2 (7), p.e24661-e24661
Main Authors: Aarntzen, Erik HJG, Srinivas, Mangala, Schreibelt, Gerty, Heerschap, Arend, Punt, Cornelius JA, Figdor, Carl G, Oyen, Wim J, de Vries, I Jolanda M
Format: Article
Language:English
Subjects:
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dendritic cell
F MRI
imaging
immunotherapy
migration
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Summary:Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.24661