Palatability and Treatment Efficacy of Various Ibuprofen Formulations in C57BL/6 Mice with Ulcerative Dermatitis

Ibuprofen, a nonsteroidal antiinflammatory drug, is a nonselective inhibitor of cyclooxygenases 1 and 2 that commonly is used for its analgesic, antiinflammatory, and antipyretic properties. We compared the palatability and efficacy of medicated water containing ibuprofen from an oral pediatric susp...

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Bibliographic Details
Published in:Journal of the American Association for Laboratory Animal Science 2012-09, Vol.51 (5), p.609-615
Main Authors: Ezell, Paula C, Papa, Luis, Lawson, Gregory W
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Dermatitis - drug therapy
Dermatitis - veterinary
Drinking
Experimental Use
Female
Ibuprofen - administration & dosage
Ibuprofen - therapeutic use
Male
Mice
Mice, Inbred C57BL
Random Allocation
Rodent Diseases - drug therapy
Skin Ulcer - drug therapy
Skin Ulcer - veterinary
Solubility
Taste
Treatment Outcome
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Summary:Ibuprofen, a nonsteroidal antiinflammatory drug, is a nonselective inhibitor of cyclooxygenases 1 and 2 that commonly is used for its analgesic, antiinflammatory, and antipyretic properties. We compared the palatability and efficacy of medicated water containing ibuprofen from an oral pediatric suspension or liqui-gel capsules in C57BL/6 and genetically engineered mice of C57BL/6 background with ulcerative dermatitis. Mice (n = 14 or 15 per group) with ulcerated skin lesions of similar average size (capsule group, 6.71 mm2; suspension group, 6.12 mm2) received ibuprofen in their drinking water at a concentration of 1 mg/mL. Water and food consumption, locomotor activity, grooming frequency, and reduction in pruritic behavior and lesion size were measured over a 9-d period. Compared with those treated with water containing the suspension, mice that received medicated water containing the liqui-gel formulation drank more (mean, 6.8 compared with 11.7 mL/d), consumed more food (4.02 compared with 2.73 g/d), and showed less pruritic behavior, greater healing (mean, 29.3% compare with 64.8%), and more locomotor activity over a 9-d period.
ISSN:1559-6109