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Extracts from lichen Lobaria retigera decrease the stemness potential of colorectal cancer cells
Lichens are symbiotic organisms with the potential to be used in the pharmaceutical industry. To identify novel lichen extracts that inhibit the stemness potential of colorectal cancer cells, we tested acetone extracts of Lobaria retigera collected in Vietnam. Crude acetone extracts of L. retigera d...
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Published in: | Materials express 2022-02, Vol.12 (2), p.234-240 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Lichens are symbiotic organisms with the potential to be used in the pharmaceutical industry. To identify novel lichen extracts that inhibit the stemness potential of colorectal cancer cells, we tested acetone extracts of Lobaria retigera collected in Vietnam. Crude acetone extracts
of L. retigera decreased spheroid formation in CSC221, DLD1, and HT29 cells. In addition, mRNA levels of genes encoding cancer stem markers aldehyde dehydrogenase-1, CD44, CD133, Lgr5, and Musashi-1 were significantly downregulated in a dose-dependent manner after treatment with L.
retigera extract. Moreover, L. retigera extract decreased the transcriptional activities of Gli and the Notch-related Hes1 promoter in reporter assays. Together, these results demonstrate that L. retigera extract is a potent inhibitor of colorectal cancer cell stemness. |
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ISSN: | 2158-5849 |
DOI: | 10.1166/mex.2022.2146 |