miR-188-5p Suppresses Gastric Cancer Cell Proliferation and Invasion via Targeting ZFP91

MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we found that the expression of miR-188-5p was downregulated in GC tissues compared with a...

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Bibliographic Details
Published in:Oncology research 2018-12, Vol.27 (1), p.65-71
Main Authors: Peng, Yuping, Shen, Xuning, Jiang, Honggang, Chen, Zhiheng, Wu, Jiaming, Zhu, Yi, Zhou, Yuan, Li, Jin
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
Female
Gastric Cancer
Humans
Lymphatic Metastasis
Male
Metastasis
MicroRNAs - genetics
Mir-188-5p
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Neoplasm Staging
Proliferation
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Ubiquitin-Protein Ligases - genetics
Zfp91
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Summary:MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we found that the expression of miR-188-5p was downregulated in GC tissues compared with adjacent normal tissues. The lowly expressed miR-188-5p was significantly associated with lymph node metastasis and advanced TNM stage. Moreover, overexpression of miR-188-5p significantly inhibited GC cell proliferation, migration, and invasion but promoted cellular apoptosis. Mechanistically, we identified transcription factor ZFP91 as a target gene of miR-188-5p in GC. We found that miR-188-5p overexpression significantly inhibited the expression of ZFP91 in GC cell lines. There was an inverse correlation between the expression of miR-188-5p and ZFP91 in GC tissues. We found that restoration of ZFP91 in miR-188-5p-overexpressed MGC-803 and SGC-7901 cells promoted cell proliferation, migration, and invasion. Finally, we also showed that overexpression of miR-188-5p inhibited tumor growth in vivo. Taken together, our findings indicated that miR-188-5p serves as a tumor suppressor in human GC by targeting ZFP91, suggesting that miR-188-5p might be a promising therapeutic target for GC treatment.
ISSN:0965-0407
1555-3906
DOI:10.3727/096504018X15191223015016