Loading…

Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome

SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β).OBJECTIVE: To assess the frequency of vitamin D deficiency among TBM patients,...

Full description

Saved in:
Bibliographic Details
Published in:The international journal of tuberculosis and lung disease 2018-01, Vol.22 (1), p.93-99
Main Authors: Dangeti, G. V., Mailankody, S., Neeradi, C., Mandal, J., Soundravally, R., Joseph, N. M., Kamalanathan, S., Swaminathan, R. P., Kadhiravan, T.
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β).OBJECTIVE: To assess the frequency of vitamin D deficiency among TBM patients, its association with treatment outcomes and correlation between vitamin D and IL-1β levels in cerebrospinal fluid (CSF).DESIGN: We prospectively studied a consecutive sample of human immunodeficiency virus-negative patients with TBM treated at a hospital in southern India. We defined good outcome as survival without severe neurological disability. Serum total 25-hydroxy vitamin D (25[OH]D) and IL-1β levels in CSF were estimated on pretreatment samples.RESULTS: We studied 40 patients with TBM; 22 (55%) patients had stage 3 disease. Treatment outcome was poor in 21 (53%) patients: 15 (38%) patients died and 6 (15%) had severe neurological disability. The overall mean serum 25(OH)D level was 32.30 ± 16.38 ng/ml. Ten (25%) patients had vitamin D deficiency (
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.17.0304