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Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome
SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β).OBJECTIVE: To assess the frequency of vitamin D deficiency among TBM patients,...
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Published in: | The international journal of tuberculosis and lung disease 2018-01, Vol.22 (1), p.93-99 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β).OBJECTIVE: To assess the frequency of vitamin D
deficiency among TBM patients, its association with treatment outcomes and correlation between vitamin D and IL-1β levels in cerebrospinal fluid (CSF).DESIGN: We prospectively studied a consecutive sample of human immunodeficiency virus-negative patients with TBM treated at a hospital
in southern India. We defined good outcome as survival without severe neurological disability. Serum total 25-hydroxy vitamin D (25[OH]D) and IL-1β levels in CSF were estimated on pretreatment samples.RESULTS: We studied 40 patients with TBM; 22 (55%) patients had stage 3 disease.
Treatment outcome was poor in 21 (53%) patients: 15 (38%) patients died and 6 (15%) had severe neurological disability. The overall mean serum 25(OH)D level was 32.30 ± 16.38 ng/ml. Ten (25%) patients had vitamin D deficiency ( |
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ISSN: | 1027-3719 1815-7920 |
DOI: | 10.5588/ijtld.17.0304 |