Melanin diagnostics with nonlinear optics: a mini-review

Optical methods are widely used to perform fundamental studies of living systems and solve problems of biomedical diagnostics. Along with the classical spectroscopy, methods of nonlinear optics (e.g., multiphoton microscopy) are also applied in biophotonics. The potential of nonlinear optical method...

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Bibliographic Details
Published in:Quantum electronics (Woodbury, N.Y.) N.Y.), 2022-01, Vol.52 (1), p.28-35
Main Authors: Shirshin, E.A., Yakimov, B.P., Budylin, G.S., Buyankin, K.E., Armaganov, A.G., Fadeev, V.V., Kamalov, A.A.
Format: Article
Language:English
Subjects:
CARS
Chromophores
FLIM
Fluorescence
Harmonic generations
Melanin
Microscopy
multiphoton microscopy
multiquantum processes
Nonlinear optics
nonlinear processes
Optical properties
Optics
pump - probe spectroscopy
Raman spectroscopy
Spectrum analysis
visualisation of fluorescence decay time
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Summary:Optical methods are widely used to perform fundamental studies of living systems and solve problems of biomedical diagnostics. Along with the classical spectroscopy, methods of nonlinear optics (e.g., multiphoton microscopy) are also applied in biophotonics. The potential of nonlinear optical methods for visualisation and analysis of the properties of endogenous chromophore molecules are considered in this minireview. Melanin – a pigment with specific spectral features of photophysical properties in the visible and near-IR ranges – is taken as an example. It is discussed what information about its localisation in tissues and structural organisation can be obtained by nonlinear optical methods: multiphoton fluorescence microscopy (including fluorescence lifetime imaging), third harmonic generation, pump – probe spectroscopy, and coherent anti-Stokes Raman spectroscopy.
ISSN:1063-7818
1468-4799
DOI:10.1070/QEL17963