Conformational transitions of macromolecules in an eluent flow and their manifestation in the chromatography of polymers

The behaviour of macromolecules in a free eluent flow, in a confined space, and in a flow passing through a pore system is considered. It is shown that the behaviour of macromolecules can be described by different theories such as the De Gennes theory and the theory of A DiMarzio and C M Guttman. Sp...

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Bibliographic Details
Published in:Russian chemical reviews 2014-01, Vol.83 (7), p.638-656
Main Authors: Kurganov, A A, Kanateva, A Yu, Orekhov, V A
Format: Article
Language:English
Subjects:
Chromatography
Computational fluid dynamics
Eluents
Fluid flow
Fluids
Fractionation
Macromolecules
Polymers
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Summary:The behaviour of macromolecules in a free eluent flow, in a confined space, and in a flow passing through a pore system is considered. It is shown that the behaviour of macromolecules can be described by different theories such as the De Gennes theory and the theory of A DiMarzio and C M Guttman. Specific features of chromatographic fractionation and separation processes with the use of membranes formed from ultrahigh-molecular-mass polymers, which are widely used as constructional materials, are discussed. To account for these features, theoretical models considering conformational transitions of macromolecules in the eluent flow and taking into account possible degradation of macromolecules under the influence of the flow are applied. The current state of theoretical and experimental studies of the behaviour of macromolecules in a fluid flow is surveyed. The bibliography includes 152 references.
ISSN:0036-021X
1468-4837
DOI:10.1070/RC2014v083n07ABEH004433