Recent advances in antifungal drug discovery based on polyene macrolide antibiotics

The review summarizes recent advances in the synthesis of new derivatives of polyene macrolide antibiotics by chemical modification and genetic engineering methods, results of structure - activity relationship studies and progress in the development of effective and safe drug formulations of this cl...

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Bibliographic Details
Published in:Russian chemical reviews 2018-12, Vol.87 (12), p.1206-1225
Main Authors: Omelchuk, Olga A., Tevyashova, Anna N., Shchekotikhin, Andrei E.
Format: Article
Language:English
Subjects:
Antibiotics
Fungicides
Genetic engineering
Organic chemistry
Toxicity
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Summary:The review summarizes recent advances in the synthesis of new derivatives of polyene macrolide antibiotics by chemical modification and genetic engineering methods, results of structure - activity relationship studies and progress in the development of effective and safe drug formulations of this class of antibiotics. Attention is focused on structural changes of polyenes, resulting in a significant decrease in toxicity with retention or even enhancement of antifungal activity. Current concepts on the mechanisms of biological action of these antiobiotics in terms of their therapeutic activity and toxicity are considered. The bibliography includes 77 references.
ISSN:0036-021X
1468-4837
DOI:10.1070/RCR4841