Evolution of bone biomechanical properties at the micrometer scale around titanium implant as a function of healing time

The characterization of the biomechanical properties of newly formed bone tissue around implants is important to understand the osseointegration process. The objective of this study is to investigate the evolution of elastic properties of newly formed bone tissue as a function of healing time. To do...

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Bibliographic Details
Published in:Physics in medicine & biology 2014-03, Vol.59 (6), p.1389-1406
Main Authors: Vayron, Romain, Matsukawa, Mami, Tsubota, Ryo, Mathieu, Vincent, Barthel, Etienne, Haiat, Guillaume
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
Biomechanics
bone
Bone Density
Elastic Modulus
elastic wave velocity
Engineering Sciences
Female
implant
Materials Testing
mechanical properties
Mechanics
micro-Brillouin scattering
nanoindentation
Osseointegration
Prostheses and Implants
Rabbits
Surface Properties
Tibia - physiology
Time Factors
Titanium
Wound Healing
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Summary:The characterization of the biomechanical properties of newly formed bone tissue around implants is important to understand the osseointegration process. The objective of this study is to investigate the evolution of elastic properties of newly formed bone tissue as a function of healing time. To do so, nanoindentation and micro-Brillouin scattering techniques are coupled following a multimodality approach using histological analysis. Coin-shaped implants were placed in vivo at a distance of 200 µm from the cortical bone surface, leading to an initially empty cavity. Two rabbits were sacrificed after 7 and 13 weeks of healing time. The histological analyses allow us to distinguish mature and newly formed bone tissue. The bone mechanical properties were measured in mature and newly formed bone tissue. Analysis of variance and Tukey-Kramer tests reveals a significant effect of healing time on the indentation modulus and ultrasonic velocities of bone tissue. The results show that bone mass density increases by 12.2% (2.2% respectively) between newly formed bone at 7 weeks (13 weeks respectively) and mature bone. The dependence of bone properties on healing time may be explained by the evolution of bone microstructure and mineralization.
ISSN:0031-9155
1361-6560
DOI:10.1088/0031-9155/59/6/1389