A pilot study of using multiphoton microscopy to diagnose schwannoma

Schwannoma is a kind of slow-growing and rare neoplasm which poses diagnostic challenges owing to its clinical silence at the presentation period. Here, a schwannoma tumor was studied by multiphoton microscopy (MPM). Results indicate that MPM is capable of identifying a schwannoma tumor without the...

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Bibliographic Details
Published in:Journal of physics. D, Applied physics Applied physics, 2019-10, Vol.52 (41), p.415401
Main Authors: Fang, Na, Wu, Zanyi, Wang, Xingfu, Cao, Ning, Lin, Yuanxiang, Li, Lianhuang, Chen, Yupeng, Zheng, Xianying, Cai, Shanshan, Kang, Dezhi, Chen, Jianxin
Format: Article
Language:English
Subjects:
image analysis
multiphoton microscopy (MPM)
schwannoma
second harmonic generation (SHG)
two-photon excited fluorescence (TPEF)
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Summary:Schwannoma is a kind of slow-growing and rare neoplasm which poses diagnostic challenges owing to its clinical silence at the presentation period. Here, a schwannoma tumor was studied by multiphoton microscopy (MPM). Results indicate that MPM is capable of identifying a schwannoma tumor without the need for labels. Based on the two-photon excited fluorescence signals from cells and blood vessels and second harmonic generation signals from collagens, several significant features for the identification of schwannoma were visualized, including the Antoni A region, Antoni B region, pericellular collagen pattern, hyalinized vessels and hyalinized stroma. These conclusions highlight the potential of MPM taken as a diagnostic method for label-free identification of schwannoma tumors by these histopathologic characteristics.
ISSN:0022-3727
1361-6463
DOI:10.1088/1361-6463/ab2fb0