Hyaluronic acid functionalized biodegradable mesoporous silica nanocomposites for efficient photothermal and chemotherapy in breast cancer

Chemotherapy is one of conventional treatment methods for breast cancer, but drug toxicity and side effects have severely limited its clinical applications. Photothermal therapy has emerged as a promising method that, upon combination with chemotherapy, can better treat breast cancer. In this contex...

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Bibliographic Details
Published in:Nanotechnology 2021-04, Vol.32 (16), p.165703
Main Authors: Zhan, Wenhua, Li, Hanrui, Guo, Yingying, Yang, Lu, Pang, Liaojun, Zhang, Chaolin
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Biocompatible Materials - chemistry
biodegradable mesoporous silica nanoparticles
breast cancer
Breast Neoplasms - therapy
Cell Death - drug effects
chemotherapy
doxorubicin
Endocytosis
Female
Humans
Hyaluronic Acid - chemistry
Hyperthermia, Induced
IR780
MCF-7 Cells
Mice
Mice, Nude
Nanocomposites - chemistry
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Phototherapy
photothermal therapy
Porosity
Silicon Dioxide - chemistry
Static Electricity
Tissue Distribution
Toxicity Tests, Acute
Tumor Stem Cell Assay
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Summary:Chemotherapy is one of conventional treatment methods for breast cancer, but drug toxicity and side effects have severely limited its clinical applications. Photothermal therapy has emerged as a promising method that, upon combination with chemotherapy, can better treat breast cancer. In this context, a biodegradable mesoporous silica nanoparticle (bMSN NPs) system was developed for loading doxorubicin (DOX) and IR780, to be potentially applied in the treatment of breast cancer. IR780 is encapsulated in the pores of bMSN NPs by hydrophobic adsorption, while DOX is adsorbed on the surface of the bMSN NPs by hyaluronic acid electrostatically, to form the bMID NPs. Transmission electron microscopy, fluorescence spectrum and UV absorption spectrum are used to prove the successful encapsulation of IR780 and the loading of DOX. In vitro experiments have shown bMID NPs present an excellent therapeutic effect on breast cancer cells. In vivo fluorescence imaging results have indicated that bMID NPs can accumulate in tumor sites gradually and achieve in vivo long-term circulation and continuous drug release. Furthermore, bMID NPs have provided obvious antitumor effects in breast cancer mouse models, thus evolving as an efficient platform for breast cancer therapy.
ISSN:0957-4484
1361-6528
DOI:10.1088/1361-6528/abda74