Systematic microdosimetric data for protons of therapeutic energies calculated with Geant4-DNA

The purpose of this study was to generate physical data needed for microdosimetry-based models of proton RBE. Our focus was on the frequency and dose average lineal energies, y F and y D. We report data for proton energies from 0.1 to 100 MeV, for spherical volumes 2-103 nm in diameter. These data w...

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Bibliographic Details
Published in:Physics in medicine & biology 2019-11, Vol.64 (21), p.215018-215018
Main Authors: Vassiliev, Oleg N, Peterson, Christine B, Cao, Wenhua, Grosshans, David R, Mohan, Radhe
Format: Article
Language:English
Subjects:
Algorithms
Geant4-DNA
microdosimetry
Monte Carlo Method
proton RBE
proton therapy
Proton Therapy - methods
Radiometry
Radiotherapy Planning, Computer-Assisted
Software
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Summary:The purpose of this study was to generate physical data needed for microdosimetry-based models of proton RBE. Our focus was on the frequency and dose average lineal energies, y F and y D. We report data for proton energies from 0.1 to 100 MeV, for spherical volumes 2-103 nm in diameter. These data were calculated using Geant4-DNA Monte Carlo software. The physics implemented in Geant4-DNA has been extensively tested for this type of calculations but data on y F and y D for protons generated with this code have been very limited. An innovative aspect of our study is that we introduced a straightforward procedure for calculation of y F and y D for polyenergetic beams and presented the data in a format that simplifies these calculations. We compared our data with previous studies that used different Monte Carlo codes and with experimental data.
ISSN:0031-9155
1361-6560
1361-6560
DOI:10.1088/1361-6560/ab47cc