Optical diagnosis of dengue virus infection in human blood serum using Raman spectroscopy

We present the optical diagnosis of dengue virus infection in human blood serum using Raman spectroscopy. Raman spectra were acquired from 18 blood serum samples using a laser at 532 nm as the excitation source. A multivariate regression model based on partial least-squares regression is developed t...

Full description

Saved in:
Bibliographic Details
Published in:Laser physics letters 2013-03, Vol.10 (3), p.35602
Main Authors: Saleem, M, Bilal, M, Anwar, S, Rehman, A, Ahmed, M
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present the optical diagnosis of dengue virus infection in human blood serum using Raman spectroscopy. Raman spectra were acquired from 18 blood serum samples using a laser at 532 nm as the excitation source. A multivariate regression model based on partial least-squares regression is developed that uses Raman spectra to predict dengue infection with leave-one-sample-out cross validation. The prediction of dengue infection by our model yields correlation coefficient r2 values of 0.9998 between the predicted and reference clinical results. The model was tested for six unknown human blood sera and found to be 100% accurate in accordance with the clinical results.
ISSN:1612-2011
1612-202X
DOI:10.1088/1612-2011/10/3/035602