Optimized single pulse stimulation strategy for retinal implants

Retinal implants offer prospects of vision restoration for some blind patients by eliciting visual percepts of spots of light called 'phosphenes'. Recently, a mathematical model has been developed that predicts patients' perception of phosphene brightness for current-driven electrical...

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Bibliographic Details
Published in:Journal of neural engineering 2013-02, Vol.10 (1), p.016003-016003
Main Authors: Savage, C O, Grayden, D B, Meffin, H, Burkitt, A N
Format: Article
Language:English
Subjects:
Blindness - physiopathology
Blindness - therapy
Brightness
Electric Stimulation Therapy - instrumentation
Electric Stimulation Therapy - methods
Electrodes
Electrodes, Implanted
Humans
Implants
Mathematical models
Models, Neurological
Patients
Perception
Phosphenes - physiology
Prostheses and Implants
Restoration
Retina - physiology
Stimulation
Visual Prosthesis
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Description
Summary:Retinal implants offer prospects of vision restoration for some blind patients by eliciting visual percepts of spots of light called 'phosphenes'. Recently, a mathematical model has been developed that predicts patients' perception of phosphene brightness for current-driven electrical stimulation of the retina. This model is explored for different stimulation parameters on a single electrode, including safety and hardware limitations, to produce phosphenes of specified brightness. We describe a procedure to derive stimulation parameters to account for such constraints, and describe methods to construct optimal stimuli in terms of producing maximal perceived brightness and efficient generation of phosphenes of a given brightness by employing minimal energy. In both cases, it is found that the resulting optimized stimulation waveforms consist of a long stimulation period, and interphase delays between initial and charge-balancing phases.
ISSN:1741-2560
1741-2552
DOI:10.1088/1741-2560/10/1/016003