Estrogenicity of the isoflavone genistein pigeon pie seeds (Cajanus cajan L. Mill sp.) on reproductive organs in rat

Genistein is a compound with structures and properties similar to 17β estradiol which can be extracted from pigeon pie. The aim of the study was to identify the genistein profiles of pigeon pie in blood, urine, and feces and their effects on uterine and vaginal tissue structures of rats. Nine female...

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Bibliographic Details
Published in:Journal of physics. Conference series 2018-05, Vol.1025 (1), p.12061
Main Authors: Primiani, Cicilia Novi, Pujiati, Hardani
Format: Article
Language:English
Subjects:
estrogenic
Estrogens
genistein
Organs
Physics
Pies
Pigeons
Sex hormones
uterine
Vagina
vaginal
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Summary:Genistein is a compound with structures and properties similar to 17β estradiol which can be extracted from pigeon pie. The aim of the study was to identify the genistein profiles of pigeon pie in blood, urine, and feces and their effects on uterine and vaginal tissue structures of rats. Nine female white rats of Sprague Dawley, 6-7 months, weighing 150-180 g, were used and given pigeon pie seed solution for 36 days, genistein profiles were analyzed using HPLC, uterine and vaginal tissue structures were analyzed with HE staining. The results showed that the genistein contained in pigeon pie was lower than that in the synthetic genistein; vaginal epithelials and uterine proliferations were indicated. To conclude, pigeon pie was found to contain genistein which is a potential alternative for a natural estrogen source.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1025/1/012061