Spectrophotometric Determination of Mebeverine hydrochloride in pharmaceutical preparation via Ion Association Reaction

We developed colorimetric method to determine Mebeverine hydrochloride. Briefly, the principle of our method is the formation of ion associated complex between the drug and phenol red indicator. The spectrum of the complex was measured with maximum absorption at 396 nm - Beers law is followed over t...

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Bibliographic Details
Published in:Journal of physics. Conference series 2018-05, Vol.1032 (1), p.12064
Main Authors: Mahdi, Abdulbari, Abas, Zainab
Format: Article
Language:English
Subjects:
Absorptivity
Colorimetry
Correlation coefficients
Ion association
Pharmaceuticals
Physics
Spectrophotometry
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Summary:We developed colorimetric method to determine Mebeverine hydrochloride. Briefly, the principle of our method is the formation of ion associated complex between the drug and phenol red indicator. The spectrum of the complex was measured with maximum absorption at 396 nm - Beers law is followed over the range over 2 - 25 ug/ml with molar absorptivity of (7.57×104L/Mol. Cm), a sandal sensitivity of (0.00615 μg. Cm -2), and the relative standard deviation RSD % (3.3974%), mean recovery was found to be in the range (96-99 %), and correlation coefficient of (R2=0.9941). However, the method accurately and successfully was performed to determine Mebeverine hydrochloride in bulk and pharmaceutical preparations.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1032/1/012064