Optimization and Assessment Orally Disintegrating Tablet of Using Biopolymer Combination

Orally Disintegrating Tablet (ODT) or a crushed tablet in the mouth is one of the most useful drug preparations for geriatric and pediatric patients who have difficulty swallowing conventional tablets. This research aims to determine the effect of single and combination biopolymers. The optimization...

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Bibliographic Details
Published in:Journal of physics. Conference series 2020-02, Vol.1462 (1), p.12047
Main Authors: Ridwanto, Lubis, M S
Format: Article
Language:English
Subjects:
Biopolymers
Carboxymethyl cellulose
Chitosan
Compressibility
Disintegration
Evaluation
Flow velocity
Hardness tests
In vitro methods and tests
Maltodextrin
Optimization
Physics
Statistical tests
Wetting
Xanthan
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Summary:Orally Disintegrating Tablet (ODT) or a crushed tablet in the mouth is one of the most useful drug preparations for geriatric and pediatric patients who have difficulty swallowing conventional tablets. This research aims to determine the effect of single and combination biopolymers. The optimization of the disintegration time of ODT preparations did by 11 formulas printed with direct press technique. It consisted of single biopolymers and combinations of Chitosan, Xanthan gum, Carboxymethyl cellulose, and Maltodextrin. Evaluation of ODT preparations begins with an evaluation of formulation, which includes the flow rate test, fixed angle, and compressibility index. The evaluation of the formulated ODT measured by size and weight uniformity test, hardness test, rigidity test, and wetting time test. Also, in vitro and vivo disintegration test. All formulas meet the ODT physical quality requirements. ODT 8 is an ODT formula that uses a disintegrant combination of biopolymer Chitosan and Maltodextrin. It shows the fastest disintegration time is 19 seconds. The statistical test showed a significant difference between the ODT formula to the optimization of disintegration time with a value of p < 0,05. ODT with a biopolymer combination has a faster disintegration than ODT with a single biopolymer.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1462/1/012047