Gold-coated iron oxide nanoparticles as a potential photothermal therapy agent to enhance eradication of breast cancer cells

Iron oxide nanoparticles (Fe3O4 NPs) possess unique physicochemical properties which make them great for biomedical applications. This study reports the development of gold (Au) coated Fe3O4 (Au-Fe3O4 NPs) for photothermal therapy to eradicate breast cancer cells (MCF-7). The spherical shape of mono...

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Bibliographic Details
Published in:Journal of physics. Conference series 2020-03, Vol.1497 (1), p.12003
Main Authors: Dheyab, M A, Aziz, A A, Jameel, M S, Khaniabadi, P M, Mehrdel, B, Khaniabadi, B M
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Breast cancer
Gold
Gold coatings
Iron oxides
Nanoparticles
Physics
Therapy
Toxicity
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Summary:Iron oxide nanoparticles (Fe3O4 NPs) possess unique physicochemical properties which make them great for biomedical applications. This study reports the development of gold (Au) coated Fe3O4 (Au-Fe3O4 NPs) for photothermal therapy to eradicate breast cancer cells (MCF-7). The spherical shape of monodisperse Au-Fe3O4 NPs with an average size of 20.8 nm was confirmed by TEM. The cell viability evaluation of Au-Fe3O4 NPs showed negligible toxicity toward MCF-7 cells after 24 h. Significant cell reduction was observed for MCF-7 (73.9%) cells following photothermal therapy at highest concentration of NPs (50 μgFe/ml) for 10 minutes illumination when compared with other intervention groups. It can be concluded that, the synthesized Au-Fe3O4 NPs is an effective and promising photothermal therapy agent for breast cancer treatment.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1497/1/012003