Development and in Vivo Evaluation of a Biodegradable Vascular Graft Reinforced with a Fused PCL Filament

Tissue-engineered vascular grafts developed for cardiovascular surgery must be fully functional after implantation, resistant to all types of kinks, compression and burst pressure. One of the approaches to improve mechanical properties includes the reinforcement with an outer polymeric sheath. This...

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Bibliographic Details
Published in:Journal of physics. Conference series 2020-08, Vol.1611 (1), p.12053
Main Authors: Krivkina, E O, Klyshnikov, K Y, Rezvova, M A, Sevostyanova, V V, Tkachenko, V O, Glyshkova, T V, Mironov, A V, Antonova, L V
Format: Article
Language:English
Subjects:
Biodegradability
Biomedical materials
Grafting
In vivo methods and tests
Mechanical properties
Physics
Sheaths
Tissue engineering
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Summary:Tissue-engineered vascular grafts developed for cardiovascular surgery must be fully functional after implantation, resistant to all types of kinks, compression and burst pressure. One of the approaches to improve mechanical properties includes the reinforcement with an outer polymeric sheath. This study was aimed at evaluating the mechanical properties of a tissue-engineered vascular graft reinforced with a fused PCL filament and in vivo testing in a carotid artery of sheep within one year.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1611/1/012053