fshr and lhr mRNA expression in granulosa cells of poor responder

In Vitro Fertilization (IVF) is one of the most commonly used procedures to help pregnancies in couples who have infertility problems. One of the problems of infertility is poor ovarian response and the woman who experiences it is known as poor responder. Poor responders do not have an adequate ovar...

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Bibliographic Details
Published in:Journal of physics. Conference series 2021-01, Vol.1725 (1), p.12057
Main Authors: Hanifah, N, Wiweko, B, Bowolaksono, A
Format: Article
Language:English
Subjects:
fshr
Gametocytes
Gene expression
In vitro fertilization
Infertility
lhr
Ovaries
Physics
poor ovarian response
real-time PCR
Statistical methods
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Summary:In Vitro Fertilization (IVF) is one of the most commonly used procedures to help pregnancies in couples who have infertility problems. One of the problems of infertility is poor ovarian response and the woman who experiences it is known as poor responder. Poor responders do not have an adequate ovarian response to gonadotropin in ovarian stimulation. The success of fertilization in poor responders tends to be low due to low quantity and is generally followed by low oocyte quality. Gonadotropins consisting of FSH and LH, play a role in follicle development and ovulation. The follicle response in capturing gonadotropins depends on the exact bond between the hormone and its receptor (FSHR and LHR) in the granulosa cells surrounding the oocyte. The purpose of this research is to know the expression level of fshr and lhr mRNA in granulosa cells of poor responders through real-time PCR method which then tested statistically using t-test. Fourteen samples of each poor responders and normal women were used in this research. The results showed insignificant differences between expression level of fshr and lhr mRNA in granulosa cells of poor responders and normal women (p > 0.05).
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1725/1/012057