Oxygen induced effects on avascular tumour growth: a preliminary simulation using an adaptive grid algorithm

Cancer cells oxygenation from surrounding healthy tissue influences tumour growth in the avascular phase. The effects induced by oxygen on cancer cells dynamics during their interaction with the urokinase plasminogen activator system, are simulated mimicking hypoxic conditions in the early stage of...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physics. Conference series 2015-09, Vol.633 (1), p.12088
Main Author: Amoddeo, Antonino
Format: Article
Language:English
Subjects:
Adaptive algorithms
Cancer
Computer simulation
Finite element method
Hypoxia
In vivo methods and tests
Oxygen
Oxygenation
Partial differential equations
Physics
Tumors
Urokinase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer cells oxygenation from surrounding healthy tissue influences tumour growth in the avascular phase. The effects induced by oxygen on cancer cells dynamics during their interaction with the urokinase plasminogen activator system, are simulated mimicking hypoxic conditions in the early stage of human tumour proliferation, using oxygen supply parameters determined from in vivo experiments. The system of six coupled partial differential equations, arising from the problem modelling, is solved over a one-dimensional domain implementing a moving mesh numerical technique, using the finite element method. Our preliminary computations show that oxygen concentration at hypoxic conditions cause cancer cells to build inhomogeneous proliferation pattern, similarly to what happens in absence of oxygen.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/633/1/012088