Study of the dopamine effect into cell solutions by impedance analysis

Electrochemical Impedance Spectroscopy (EIS) has become a technique that is frequently used for biological assays. Impedance is defined as a complex - valued generalization of resistance and varies depending on its use per application field. In health sciences, bioimpedance is widely used as non-inv...

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Bibliographic Details
Published in:Journal of physics. Conference series 2017-11, Vol.931 (1), p.12010
Main Authors: Paivana, G, Apostolou, T, Kaltsas, G, Kintzios, S
Format: Article
Language:English
Subjects:
Catecholamine
Dopamine
Electrochemical impedance spectroscopy
Impedance measurement
Neurotransmitters
Physics
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Summary:Electrochemical Impedance Spectroscopy (EIS) has become a technique that is frequently used for biological assays. Impedance is defined as a complex - valued generalization of resistance and varies depending on its use per application field. In health sciences, bioimpedance is widely used as non-invasive and low cost alternative in many medical areas that provides valuable information about health status. This work focuses on assessing the effects of a bioactive substance applied to immobilized cells. Dopamine was used as a stimulant in order to implement impedance analysis with a specific type of cells. Dopamine constitutes one of the most important catecholamine neurotransmitters in both the mammalian central and peripheral nervous systems. The main purpose is to extract calibration curves at different frequencies with known dopamine concentrations in order to describe the behavior of cells applied to dopamine using an impedance measurement device. For comparison purposes, non-immobilized cells were tested for the same dopamine concentrations.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/931/1/012010