Spectroscopic techniques to study the immune response in human saliva

Studies of the immune response dynamics by means of spectroscopic techniques, i.e., laser correlation spectroscopy and fluorescence spectroscopy, are described. The laser correlation spectroscopy is aimed at measuring sizes of particles in biological fluids. The fluorescence spectroscopy allows stud...

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Bibliographic Details
Published in:Journal of physics. Conference series 2018-01, Vol.956 (1), p.12009
Main Authors: Nepomnyashchaya, E, Savchenko, E, Velichko, E, Bogomaz, T, Aksenov, E
Format: Article
Language:English
Subjects:
Algorithms
Fluorescence
Immune system
Lasers
Physics
PIN diodes
Saliva
Signal processing
Spectroscopic analysis
Spectrum analysis
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Description
Summary:Studies of the immune response dynamics by means of spectroscopic techniques, i.e., laser correlation spectroscopy and fluorescence spectroscopy, are described. The laser correlation spectroscopy is aimed at measuring sizes of particles in biological fluids. The fluorescence spectroscopy allows studying of the conformational and other structural changings in immune complex. We have developed a new scheme of a laser correlation spectrometer and an original signal processing algorithm. We have suggested a new fluorescence detection scheme based on a prism and an integrating pin diode. The developed system based on the spectroscopic techniques allows studies of complex process in human saliva and opens some prospects for an individual treatment of immune diseases.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/956/1/012009