Transparent injectable sericin-honey hydrogel with antioxidant and antibacterial activities combined with feeding sericin accelerates diabetic wound healing

Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent antioxidant activity was prepared. Besides, the sericin-honey hydrogel is transparent, i...

Full description

Saved in:
Bibliographic Details
Published in:Biomedical materials (Bristol) 2024-05, Vol.19 (3), p.35008
Main Authors: Wei, Yongkang, Li, Yanwei, Li, Yurong, Xu, Gang, Wu, Tangfeng, Li, Xiang, Ye, Ruixi, Xi, Meilin, Li, Xiaomei, Zhang, Guozheng, Zhang, Yeshun
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antioxidants
biocompatibility
Diabetes Mellitus
diabetic wound healing
Honey
Hydrogels - pharmacology
Mice
sericin
Sericins - pharmacology
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent antioxidant activity was prepared. Besides, the sericin-honey hydrogel is transparent, injectable, sticky, highly porous, and has good swelling properties, antibacterial activity, and cell compatibility. Based on its good performance , sericin-honey hydrogel achieved effective treatment on a mouse diabetic wound model, significantly accelerating the wound healing process. Furthermore, the combined effect of feeding sericin solution played a positive role in strengthening the effect of diabetic wound repair.
ISSN:1748-6041
1748-605X
DOI:10.1088/1748-605X/ad2ed4