Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry-a pilot study on tobacco smokers

Online breath analysis is an attractive approach to track exhaled compounds without sample preparation. Current commercially available real-time breath analysis platforms require the purchase of a full mass spectrometer. Here we present an ion source compatible with virtually any preexisting atmosph...

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Bibliographic Details
Published in:Journal of breath research 2016-02, Vol.10 (1), p.016010-016010
Main Authors: Gaugg, Martin Thomas, Gomez, Diego Garcia, Barrios-Collado, Cesar, Vidal-de-Miguel, Guillermo, Kohler, Malcolm, Zenobi, Renato, Martinez-Lozano Sinues, Pablo
Format: Article
Language:English
Subjects:
breath analysis
Breath Tests - methods
Exhalation
heavy volatiles
high mass resolution
Humans
ionizer
Ions
mass spectrometry
Mass Spectrometry - methods
Pilot Projects
real-time
Smoking - metabolism
Spectrometry, Mass, Electrospray Ionization
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Summary:Online breath analysis is an attractive approach to track exhaled compounds without sample preparation. Current commercially available real-time breath analysis platforms require the purchase of a full mass spectrometer. Here we present an ion source compatible with virtually any preexisting atmospheric pressure ionization mass spectrometer that allows real-time analysis of breath. We illustrate the capabilities of such technological development by upgrading an orbitrap mass spectrometer. As a result, we detected compounds in exhaled breath between 70 and 900 Da, with a mass accuracy of typically  
ISSN:1752-7155
1752-7163
1752-7163
DOI:10.1088/1752-7155/10/1/016010