BDNF (brain-derived neurotrophic factor) serum levels in schizophrenic patients with cognitive deficits

Schizophrenia is a complex neurodevelopmental disorder with cognitive impairment as the main part. BDNF regulates aspects of developmental plasticity in the brain and is involved in cognitive function. Cognitive functions include capabilities such as attention, executive functioning, assessing, moni...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2018-03, Vol.125 (1), p.12181
Main Authors: Utami, N, Effendy, E, Amin, M M
Format: Article
Language:English
Subjects:
Brain
Brain-derived neurotrophic factor
Cognitive ability
Developmental plasticity
Enzyme immunoassay
Ethical standards
Executive function
Immunoassay
Mental disorders
Neurodevelopmental disorders
Neuroplasticity
Patients
Schizophrenia
Serum levels
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Summary:Schizophrenia is a complex neurodevelopmental disorder with cognitive impairment as the main part. BDNF regulates aspects of developmental plasticity in the brain and is involved in cognitive function. Cognitive functions include capabilities such as attention, executive functioning, assessing, monitoring and evaluating. The aim of the study was to know the BDNF levels in schizophrenic patients with cognitive deficits. The study was held in October 2016 - March 2017, and was the first in Indonesia, especially in North Sumatra. The study was approved by the medical ethics committee of the University of North Sumatera. The study is descriptive based on a retrospective method with cross-sectional approach. The subject is 40 male schizophrenia. Cognitive deficits were assessed by MoCA-Ina. BDNF serum levels were analyzed using the quantitative sandwich enzyme immunoassay. The average MoCA-Ina score is 21.03±5.21. This suggests that there is a cognitive function deficit in schizophrenic patients. The mean serum BDNF level was 26629±6762. MoCA-Ina scores in schizophrenic patients
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/125/1/012181