The Benefits of Ethanolic Extract of Plectranthus amboinicus Lour Spreng on Rats Hematology Profile that Provided with Rhodamine-B

The objective of this study determines the effect of Plectranthus amboinicus L. Spreng ethanol extract on the hematological profile of rats exposed to Rhodamine-B. This study used 40 male rats that divided into eight groups consisted of five rats in each group. Group P0 was given 1% CMC. P1, P2, P3...

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Published in:IOP conference series. Earth and environmental science 2018-11, Vol.187 (1), p.12028
Main Authors: Silitonga, Melva, Restuati, Martina, Silitonga, Pasar Maulim
Format: Article
Language:English
Subjects:
Erythrocytes
Ethanol
Hematocrit
Hematology
Hematology profile
Hemoglobin
Leukocytes
Lour Spreng
Platelets
Plectranthus amboinicus
Rhodamine
Rhodamine-B
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Summary:The objective of this study determines the effect of Plectranthus amboinicus L. Spreng ethanol extract on the hematological profile of rats exposed to Rhodamine-B. This study used 40 male rats that divided into eight groups consisted of five rats in each group. Group P0 was given 1% CMC. P1, P2, P3 groups were given 350, 700 and 1050 mg of ethanolic extract of Plectranthus amboinicus L. Spreng (EEP)/kg bw as preventive dose, and P4, P5, P6 groups were given 350, 700 and 1050 mg EEP/kg bw as a curative action, whereas Positive Control (PC) is given 980 mg of Rhodamine-B/kg bw. Preventive treatment was done by giving EEP from the 1st to 42nd day and Rhodamine-B was given from 21st to 42ndday. Whereas in curative treatment is done by inducting Rhodamine-B from the first to the 21st day and followed by EEP from the 22nd until the 42nd day. Parameters being observed were Erythrocyte, Total Leukocyte Count (TLC), Platelet (Plt), Hematocrit (Ht), Hemoglobin (Hb), MCH, MCHC and MCV.The results revealed that Rhodamine-B decreased the erythrocyte level significantly and there was no difference between the prevention and curative treatment. Platelets were decreased significantly in PC treatment but are similar to controls. The treatment in P4 and P5 showed significant increase in platelets level. The total leukocyte increased significantly in P6 treatment. The hematocrit (Ht) profile did not change in all treatments. The hemoglobin profile remains normal, however there was a significant decreased in PC and P6 treatment. MCV and MCH were increased significantly only in PC treatment. There was no difference in MCHC profile in all treatments of EEP and Rhodamine-B.
ISSN:1755-1307
1755-1315
1755-1315
DOI:10.1088/1755-1315/187/1/012028