Pre-clinical studies of reparative properties of fetoplacental peptide bio-regulators

Cell technology can bring veterinary medicine to a new level of development. Despite the success of modern veterinary medicine, this area is understudied having enormous opportunities and unexpected dangers. This article provides experimental data on the effect of the biologically active preparation...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2019-10, Vol.341 (1), p.12155
Main Authors: Pereryadkina, S P, Ushakov, M A, Kocharyan, V D, Bakanova, K A
Format: Article
Language:English
Subjects:
Abnormalities
Animal models
Animals
Biological activity
Biological effects
Blistering
Blisters
Burns (injuries)
Embryogenesis
Embryonic growth stage
Embryos
Exudation
Hyperemia
Inflammation
Laboratory animals
Medicine
Placenta
Skin
Veterinary medicine
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Summary:Cell technology can bring veterinary medicine to a new level of development. Despite the success of modern veterinary medicine, this area is understudied having enormous opportunities and unexpected dangers. This article provides experimental data on the effect of the biologically active preparation "FPB" on laboratory animals, artificially created models of the inflammatory process. We took into account the effect of placental preparation on rat embryogenesis and embryo developmental abnormalities, since the ultimate goal of this preparation is treatment of the obstetric-gynecological pathology in dairy cows. The studies have shown that the use of drugs based on the fetoplacental complex (10%-30%) stimulates reparative and regenerative skin properties. The local irritant effect of 10% and 30% drug on the mucous eye membrane and skin of rats upon was not pronounced. In a series of experiments on reparative properties of the drug, burns caused skin hyperemia with marked exudation on the skin surface. On the sixth day of the study, the area of the burn decreased by 5.8% in the first group, by 7.7.% in the second group, and by 2.4% in the control group. On the 15th day, the blisters became crusted, in 65.0% of the animals, their rejection was observed. The area of the wound decreased by 68.0%, while in the the control group, it decreased by 31.8%. The biologically active placental preparation did not have mutagenic and embryotoxic effects during the critical periods of embryo development.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/341/1/012155